Author

Hao-Chen Wang

3 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Review Open access Aug 2026

MultiFlow: coupled flow matching for predicting single-cell multiomic perturbation responses in unseen cellular contexts

Predicting cellular responses to perturbation requires resolving coordinated changes across molecular layers, yet most single-cell perturbation models focus on transcriptional responses alone. Here we present MultiFlow, a coupled flow-matching framework that unifies generation and perturbation prediction of paired gene...

Hao-Chen Wang, Charming Zhang, Meng-Ran Zhang et al. · bioRxiv · 0 citations

Open access Aug 2026

RegFM: an interpretable context-aware foundation model for human transcriptional regulation

RegFM emerges as a scalable and interpretable framework for modeling human transcriptional regulation and provides insights into context-dependent gene regulatory programs.

Zijing Gao, Yining Sun, Hao-Chen Wang et al. · bioRxiv · 0 citations

#machine learning Preprint Sep 2026

Code-to-Harness: Distilling Black-Box Optimizers from Self-Play

This work studies low-budget black-box optimization, where unaided language models remain well below strong classical optimizers and attains the lowest regret on a sealed YouTube reward-tuning production benchmark.

Yi Wu, Zheng Ren, Zhi-Yu Hu et al. · 0 citations