Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics.
A unified view is provided of how genome structure is established, how it relates to function, and how its disruption contributes to tumorigenesis, suggesting that alterations in genome structure can, in some contexts, actively reshape oncogenic programs.
Rebecca G. Smith, Hannah M. Wilson, Kathleen L. Schiela et al.
· Genes & Development · 0 citations