Hannah Gilliam-Vigh

Short term overfeeding disrupts small intestinal barrier integrity and activates hepatic immunity in healthy men

Summary Obesity is associated with intestinal barrier dysfunction and low-grade inflammation, prompting investigations of early human adaptations to overnutrition. In a controlled “holiday-style” overfeeding model, healthy men underwent a 2-week hypercaloric, sedentary lifestyle with 8-week follow-up (ClinicalTrials.go...