Hanlin Zhong

Gut dysbiosis impairs HPA axis function and exacerbates post-stroke inflammation in high-fat diet-fed male mice

ABSTRACT High-fat diet (HFD)-induced metabolic stress is associated with impaired hypothalamic–pituitary–adrenal (HPA) axis function, but its impact on stroke outcomes and the role of the gut microbiota remain unclear. In a mouse middle cerebral artery occlusion (MCAO) model, we found that HFD induced gut dysbiosis, su...