High-content imaging-based screens with small molecule or genetic perturbations rely on rich optical phenotypes, yet how distinct subcellular markers contribute complementary biological information remains unclear. Here, we introduce CellMAPP, a multiplexed organelle imaging platform that uses optical pooled screens wi...
Paula Coelho, Ana Carolina Leote, He-Ming Yao et al.· bioRxiv· 0 citations
This work assembled 18 human kidney single-cell and single-nucleus RNA-sequencing datasets spanning 232 donors and five major disease contexts into a uniformly processed and computationally integrated Human Kidney Cell Atlas (HKCA).
Konstantinos Stasinos, Han-Chen Wang, A. Predeus et al.· bioRxiv· 0 citations
This work introduces AutoScreen, an AI co-scientist system supporting target discovery through both Pre-screen Design, which constructs perturbation libraries de novo from free-text research descriptions, and Post-screen Analysis, which re-ranks experimental screen hits by integrating statistical scores with biological...
Yuan-Hao Qu, Xu-Feng Liu, Xiao-Tong Wang et al.· bioRxiv· 0 citations
Perturb-ME, along with agentic interpretation, provide a scalable framework for comprehensive functional discovery from phenotype-enriched genetic screens and combines genome-scale CRISPR screening, phenotype-based enrichment and multimodal single-cell profiling.
Han-Chen Wang, Jiacheng Gu, Chris J. Frangieh et al.· bioRxiv· 0 citations
Biomni envisions artificial intelligence augmenting human scientists and accelerating discovery by interpreting multi-modal datasets, optimizing protein stability, orchestrating wet-lab instruments, and generating experimentally testable protocols.
Kexin Huang, Serena Zhang, Hanchen Wang et al.· Science· 19 citations· ⚡2
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.