Molecular docking, dynamics, and ADME studies of new isatin derivatives as histone deacetylase (HDAC) inhibitors
Histone deacetylase-2 (HDAC-2) is an important therapeutic target in cancer treatment. Isatin derivatives have attracted considerable interest in medicinal chemistry because of their diverse biological activities. The present study aimed to investigate a series of newly designed isatin derivatives as HDAC-2 inhibitors...