Author

Han Xie

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Open access Sep 2026

Discovery and Optimization of Imidazothiazole Carboxamides as Novel Anti-Tuberculosis Agents

This structurally differentiated chemotype provides a promising starting point for further optimization as antitubercular agent and led to analogs 21 and 24 with substantially improved antimycobacterial potency.

Leo Meng, D. Grant, Han Xie et al. · bioRxiv · 0 citations

Open access Sep 2026

Discovery and Structure–Activity Relationship Optimization of a Novel Rv1625c Agonist Chemotype with Antitubercular Activity

Rv1625c/Cya has emerged as a promising target for the development of treatment-shortening therapies for tuberculosis. Screening of an Enamine compound library identified sBQQ004 as an initial hit, and rapid hit optimization led to compound 1, which was subsequently confirmed as an Rv1625c/Cya agonist. Structure–activit...

Han Xie, Paridhi Sukheja, Kirsten T. Tolentino et al. · bioRxiv · 0 citations