Author

Han-Ming Hao

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Open access Sep 2026

Snail2: roles and regulatory mechanisms in development and disease

Snail2 (SNAI2/Slug), a core C2H2 zinc-finger transcription factor of the Snail superfamily, functions as a master regulator of epithelial-mesenchymal transition (EMT) and cellular plasticity in development and disease. Unlike other EMT transcription factors that drive complete transition, Snail2 distinctively promote...

Yi-Meng Chen, Zheng-Lin He, Yi-Ping Jiao et al. · Cell Death Discovery · 0 citations

Review Open access Sep 2026

Immunosuppressive tumor microenvironment and immunotherapy resistance of esophageal carcinoma

Esophageal carcinoma (EC) remains one of the most lethal malignancies, with a five-year survival rate of only 15-25% in advanced stages. Although immunotherapy including immune checkpoint inhibitors (ICIs) and antibody-based therapies have improved clinical outcomes, durable responses are confined to a minority of pati...

Zheng-Lin He, Han-Ming Hao, Xin-Yang Shu et al. · Frontiers in Immunology · 0 citations