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Author

Han-Mei Yang

2 papers indexed here

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Open access Sep 2026

Structural basis of internal Vangl2 peptide recognition by the Dvl2 PDZ domain

Planar cell polarity (PCP) signaling is an evolutionarily conserved pathway that regulates cellular asymmetry and tissue organization during development and homeostasis. Dysregulation of PCP signaling is associated with developmental defects and human diseases, highlighting its essential biological functions. Core PCP...

Han-Mei Yang, Hua-Qing Deng, Ke-Ru Chen et al. · 0 citations
Review Open access Sep 2026

Harnessing tumor immune checkpoints for autoimmune disease therapeutics

Immune checkpoint (IC) pathways, originally identified in T-cell exhaustion in cancer, are increasingly recognized as key modulators of immune tolerance in autoimmune diseases (ADs). In ADs, these molecules function more accurately as inhibitory receptors (IRs) that fine-tune, rather than inducing classical exhaustion...

Han-Mei Yang, Ping Zhang, Yi Wu et al. · 0 citations

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