Author

Han Lin

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Jul 2026

FAL1 facilitates cisplatin resistance of lung adenocarcinoma via BMI1/BIM-mediated apoptosis–autophagy interaction

It is demonstrated that FAL1 drives cisplatin resistance in LUAD by shifting the balance between apoptosis and autophagy through the BMI1/BIM axis.

Teng Ma, Yang Xia, Yijiang Chen et al. · Molecular and Cellular Bioch... · 0 citations

Open access Jul 2026

ERK/GATAD2A/SAA1 axis drives osimertinib resistance via NF-κB and macrophage reprogramming in EGFR-mutated lung adenocarcinoma

Target neutralization of SAA1 synergized robustly with osimertinib to reverse immunosuppressive remodeling and induce profound tumor regression in multiple preclinical models, highlighting SAA1 neutralization as a tractable combinatorial strategy to enhance EGFR-TKI efficacy in LUAD.

Jun-Kan Zhu, Shencheng Ren, Tao Cheng et al. · Journal of Experimental &amp... · 0 citations