A SIRT1-PERK-HSPA5-MARCHF1 Proteostasis Axis Controls GPX4 Stability and Ferroptotic Susceptibility in Hepatic Stellate Cells.
AIMS Liver fibrosis is a chronic inflammatory condition characterized by excessive extracellular matrix accumulation driven by hepatic stellate cell (HSC) activation, and inducing HSC ferroptosis represents an effective strategy to restrain fibrogenesis. In this study, liver fibrosis was induced in C57BL/6J mice by int...