Open access
Oct 2026
Disentangling polymer confinement from specific-folding interactions reveals the drivers of Escherichia coli chromosome organization
Abstract The three-dimensional organization of the bacterial chromosome is critical for gene regulation. Chromosome conformation capture (Hi-C) has enabled genome-wide mapping of chromosomal folding, yet ensemble-averaged contact maps entangle biologically specific-folding interactions (SFIs) with nonspecific polymer c...
Pourya Delafrouz, Tanya Nesterova, Frances E. Harris et al.
· Nucleic Acids Research · 0 citations