Insights into the protective role of trigonelline in 5-fluorouracil-induced lung injury: targeting oxidative stress, inflammation, and apoptosis.
5-Fluorouracil (5-FU) is an effective chemotherapeutic agent; however, its clinical use is frequently limited by toxicity in normal tissues, including the lungs. This study investigated the prophylactic protective effect of trigonelline (TRIG), a naturally occurring alkaloid, against 5-FU-induced pulmonary injury, with...