Preprint
Aug 2026
Concept-based explanation of gene expression prediction from H&E images
Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer (ViT)-based models are largely limited to local heatmaps and do not reveal how morphological concepts contribute to ST...
Amos Muench, J. Thielmann, Reduan Achtibat et al.
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