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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

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Haiyan Wei

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Open access Aug 2026

JMJD5 Dioxygenase Inhibition Mechanism by 2-Hydroxyglutarate: A QM/MM Study

Jumonji domain-containing protein 5 (JMJD5) is a FeII/2-oxoglutarate-dependent oxygenase implicated in cellular metabolism and cancer-related processes. Although the oncometabolite 2-hydroxyglutarate (2-HG) is known to inhibit JMJD5, the molecular origin of this inhibition remains unclear. Here, molecular dynamics si...

Xue-Yi Ji, Ziyue Huang, Yingqi Li et al. · 0 citations

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