Aug 2026
Design, synthesis, and antitumor evaluation of celastrol derivatives targeting PRDX3.
In vivo efficacy evaluation demonstrated that 10d exhibited significantly superior tumor suppression in a subcutaneous xenograft model of H1975 tumors compared to celastrol, without causing notable systemic toxicity such as significant body weight loss.
Yu-Chi Zhao, Hanshuang Cai, Lijuan Zuo et al.
· European journal of medicina... · 0 citations