Author

Hai-Ying Chen

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Open access Oct 2026

CDK9 Degradation Suppresses Gastroesophageal Cancer Growth and Overcomes Radiation Resistance through Chromatin Remodeling and YAP1/TEAD Downregulation.

Gastroesophageal adenocarcinoma (GEAC) remains a highly aggressive malignancy with limited effective targeted therapies. Cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation, has been implicated in oncogenic processes across multiple cancer types; however, its functional role and therapeutic...

Y. Zhang, Mikel Ghelfi, Yu Xue et al. · Cancer Letters · 0 citations

Review Open access Sep 2026

NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting

The biological functions of the NSD family of histone methyltransferases are summarized, their oncogenic mechanisms in solid tumors are discussed, and recent progress in therapeutic targeting is highlighted.

Y. Zhang, Andrew Plenn, Joey Sun et al. · International Journal of Mol... · 0 citations

Open access Aug 2026

Pharmacologic Inhibition of SOX9-CDK4 by CYD-4-61 Impairs Gastric Adenocarcinoma Growth and Amplifies Anti-PD-1 Response.

Findings identify the BAX-SOX9-CDK4 axis as an important mechanism contributing to the antitumor activity of CYD-4-61 and provide a strong preclinical rationale for its further development as a therapeutic strategy for aggressive GAC.

Geng-Yi Zou, Katsuhiro Yoshimura, Yibo Fan et al. · Cancer Letters · 0 citations