Hai-Yan Zhu

MMP8 exacerbates sepsis-induced pulmonary vascular leakage by disruption of endothelial VE-cadherin through ERK signalling

Endothelial dysfunction is a major contributor to multi-organ failure and mortality in sepsis, with the lungs being particularly susceptible to vascular leakage. Previous studies have implicated matrix metalloproteinase 8 (MMP8) in sepsis pathogenesis. However, the role of MMP8 in maintaining endothelial barrier integr...