Author

Hai-Xue Zheng

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Open access Sep 2026

A859L Plays a Critical Role in Facilitating Efficient African Swine Fever Virus Replication

African swine fever virus (ASFV) is a highly pathogenic agent that poses a severe threat to the global swine industry. The biological function of A859L, an ASFV-encoded RNA helicase, remains largely elusive. Here, we show that A859L is highly conserved across diverse ASFV isolates and belongs to the SF2 superfamily of...

Xiang-Tao Zhu, Hong-Yu Yan, Wan-Hui Zhou et al. · Viruses · 0 citations

Open access Sep 2026

LY6E regulates Pseudorabies virus early infection via impairing viral internalization

Pseudorabies virus (PRV) causes Aujeszky’s disease, posing an emerging threat to the livestock industry and raising concern for human health. Host cells employ a wide range of intrinsic factors to combat viral infections; however, the host factors involved in restricting PRV entry remain poorly understood. In this stud...

Tanveer Ali Fazlani, Tian-Xing Cao, Yi-Chao Wang et al. · Veterinary Research · 0 citations

Aug 2026

TOLLIP suppresses picornavirus internalization by targeting and degrading VP1 protein through selective autophagy.

Foot-and-mouth disease virus (FMDV) represents a major threat to global livestock production. The capsid protein VP1 is crucial for infection; however, the host factors and mechanisms responsible for VP1 restriction remain poorly understood. We previously identified the host chaperone DNAJA3 as a host restriction facto...

Wei Zhang, Yang Yang, Wenhua Shao et al. · Autophagy · 0 citations