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Author

Hai-Xia Wang

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Review Jul 2026

The Piezo1/YAP mechanotransduction axis: From mechanistic insights to therapeutic perspectives in disease.

The role of the Piezo1/YAP axis is focused on in regulating key physiological processes such as skeletal development, neural plasticity, macrophage polarization, epithelial homeostasis and barrier function, and cardiac development.

Rui-Ming Wen, Hai-Xia Wang, Wei-Feng Pan et al. · 0 citations
Review Jul 2026

Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation.

The molecular mechanisms, pathological roles, and evolving clinical applications of GPNMB in cancer are dissected, highlighting current challenges and future directions for precision oncology.

Hai-Xia Wang, Rui-Ming Wen, Zhongwei Yang et al. · 0 citations
Review Open access Jul 2026

TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.

The objective is to elucidate the context-dependent roles of TREM2 by analyzing consensus mechanisms, sources of discrepancy, and translational implications, thereby providing a theoretical framework and strategic direction for more precise TREM2-targeted interventions.

Hai-Xia Wang, Rui-Ming Wen, Emily Parker et al. · 0 citations

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