Hai-Tong Wan

Deciphering traditional Mongolian medicine Sugemule-3 decoction: Chemical profiling and therapeutic effect evaluation against myocardial fibrosis.

BACKGROUND Sugemule-3 Decoction (SD3) is developed from 'Four Continuations of Medicine', one of the traditional Mongolian medical classics compiled in the late 8th century. SD3 consists of Baidoukou (Amomum kravanh Pierre ex Gagnep.), Xianghanqin (Cuminum cyminum L.) and Biba (Piper longum L.). It has been demonstrate...

Epigenetic Regulatory Networks in Cardiac Fibrosis: Therapeutic Targets, Crosstalk, and Future Directions

Abstract Cardiac fibrosis is a central driver of pathological cardiac remodeling and a critical risk factor for the progression to heart failure. Cardiac fibrosis may induce myocardial ischemia and hypoxia, impaired cardiac function, and arrhythmias, and is thereby intimately linked to escalating cardiac mortality. Epi...

Ellagic acid attenuates myocardial fibrosis by suppressing Bmi1-mediated inhibition of the p53/p21 pathway in cardiac fibroblasts.