Open access
Oct 2026
UBE2C–TRIM21-driven NOS2 degradation stabilizes Tregs and suppresses pyroptotic signaling in thyrocytes in Hashimoto’s thyroiditis
Hashimoto’s thyroiditis (HT) features persistent immune intolerance and progressive thyrocyte injury, yet the mechanistic linkage between regulatory T cell (Treg) instability and inflammasome-driven inflammatory damage in thyroid follicular cells remains unclear. We hypothesized that a Treg-intrinsic proteostasis modul...
Xin-Yuan Cui, Yan-Ting Mao, Bo-Jin Xu et al.
· Inflammation Research · 0 citations