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Haiming Luo

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Open access Sep 2026

Size-tailored nanoparticle-antibody conjugates overcome hepatic sequestration in Alzheimer's disease treatment.

Antibody-based immunotherapy targeting amyloid-β (Aβ) is a promising approach for Alzheimer's disease (AD). However, its efficacy is limited by rapid hepatic sequestration, complement activation, and liver dysfunction. In this study, we synthesized low-immunogenic 450-nm functionalized mesoporous silica nanoparticles (...

Xue-Wei Du, Ni Liu, Tao-Ping Zhang et al. · 0 citations
Aug 2026

Reagentless, Wash-Free Multiplexed Analysis of Plasma Biomarkers for Alzheimer’s Disease Diagnosis via an Antibody-Based Molecular Pendulum

A single-pot electrochemical sensing platform that enables rapid and ultrasensitive quantitative detection of AD biomarkers directly from untreated blood or plasma within 20 min of collection, without sample preparation, washing, or using additional reagents is reported.

Xue-Wei Du, Tao-Ping Zhang, Zhongzhong Wan et al. · 0 citations

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