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Author

Hai-Li Zhang

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Review Aug 2026

CRISPR/Cas trans-cleavage activity in pathogen detection: research progress and innovations.

The integrated CRISPR/Cas detection workflow from sample collection and processing through final result output is assessed, and the intrinsic characteristics of Cas effector proteins with respect to target enrichment, reporter molecules, readout formats, sample background, and validation design are analyzed.

Rong Gao, Hong-Li Jin, Tian-Yi Zhang et al. · 0 citations
Open access Sep 2026

RABV P protein activates the GSK3β-NF-κB signaling pathway to promote viral replication by interacting with the host protein Snapin

This study reveals Snapin, a neuronal trafficking regulator, to be a critical host factor co-opted by RABV to enhance neuroinvasion and identifies a Snapin-dependent GSK3β/NF-κB axis as a potential therapeutic target for rabies treatment.

Yu-Jie Bai, Yong-Sai Liu, Xiao-Yu Wu et al. · 0 citations
Open access Aug 2026

A streamlined visual RT-RAA-CRISPR/Cas12a assay for rapid detection of Schmallenberg virus

A visual nucleic acid detection assay for SBV that combines reverse transcription recombinase‑aided amplification (RT‑RAA) with the CRISPR/Cas12a system, targeting conserved regions of the SBV S gene holds promise for further clinical validation, although its diagnostic utility in authentic clinical specimens remains t...

Ziyang Han, Yu-Jie Bai, Pei Huang et al. · 0 citations

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