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Hai-Feng Chen

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Aug 2026

Iterative Enoyl Reduction by a FabV-Family Enzyme Expands the Chemical Landscape of Discrete Polyketide Synthases.

PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.

Yan Gao, Kai Jiang, Yu-Han Dai et al. · 0 citations
Review Open access Jul 2026

AlphaFold-based peptide structure prediction: Opportunities, limitations, and future directions.

Accurate prediction of peptide structures and peptide-receptor complexes is essential for rational peptide drug development. However, the inherent conformational flexibility of short and disordered peptides presents a fundamental challenge. The AlphaFold model series, which has progressed from AlphaFold2 through AlphaF...

Buke Zhang, Junjie Zhu, Hai-Feng Chen et al. · 0 citations

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