Iterative Enoyl Reduction by a FabV-Family Enzyme Expands the Chemical Landscape of Discrete Polyketide Synthases.
PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.