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Review Sep 2026

From molecular characteristics to clinical practice: current status and future prospects of immunotherapy for SMARCA4-deficient tumors.

SMARCA4-deficient tumors arise from mutations, deletions, or fusions of the SMARCA4 gene that abrogate the function of its encoded protein BRG1. Defined by profoundly disrupted chromatin remodeling, these tumors carry a dismal prognosis, respond poorly to conventional therapies, and lack any standardized treatment appr...

Rina Qu, Xiang Li, Huan Zhu et al. · 0 citations

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