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Author

Hai-Bing Zhou

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Sep 2026

Identification of Novel Acylthiourea-Based PROTACs Exhibiting Broad-Spectrum Antiviral Activity against Enteroviruses.

A novel type of acylthiourea-based proteolysis-targeting chimeras (PROTACs) to induce targeted protein degradation to induce targeted protein degradation in enteroviruses, showing strong anti-EV71 activity by inhibiting viral replication.

Yu-Meng Cai, Mao-Ze Yang, Lei Yu et al. · 0 citations
Jul 2026

A Novel Dual-Targeting PROTAC Overcomes Endocrine Resistance by Engaging Orthosteric and Allosteric Sites of Estrogen Receptor α.

The lead compound P5 demonstrated high binding affinities for LBP and CBS sites, potent antiproliferative activity, and efficient ERα degradation efficacy across a panel of breast cancer cell lines via the ubiquitin-proteasome system.

Chao Wang, Bin Xu, Li-Lan Xin et al. · 0 citations

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