Potential Contribution of the Microbiota-Gut-Brain Axis to Doxorubicin-Associated Cognitive Impairment: Mechanisms, Evidence, and Therapeutic Opportunities.
Key priorities are longitudinal human cohorts with pretreatment baselines and repeated multi-omics and cognitive assessments; animal studies that test temporal precedence and causal rescue or pathway blockade in the same model; mediation analyses that determine whether microbial or metabolic changes lie between treatme...