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Author

Ha Yeon Park

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Aug 2026

Polyaspartamide-Mediated Messenger RNA Delivery Enables Efficient Ex Vivo Engineering of Chimeric Antigen Receptor Natural Killer Cells via Enhanced Cellular Internalization.

Engineered natural killer (NK) cells expressing chimeric antigen receptor (CAR) represent a promising alternative to CAR T-cell therapy due to their allogeneic potential. However, current CAR NK cell production relies on lentiviral or retroviral transduction to achieve stable CAR expression, requiring complex, multiste...

Ha Yeon Park, Seon-Jeong Kim, Kyuree Kim et al. · 0 citations
Open access Sep 2026

Phosphatidylserine-Engineered Lipid Nanoparticles Enable Systemic mRNA Delivery to the Central Nervous System

Intravenously administered lipid nanoparticles (LNPs) predominantly accumulate in the liver, limiting mRNA delivery to extrahepatic tissues, particularly the central nervous system (CNS). Here, we report a ligand-free strategy for systemic CNS delivery using phosphatidylserine (PS, 1 mol %)-engineered LNPs, in which...

Jun Hyeong Hong, Jae Hoon Kim, Seung-Yeul Lee et al. · 0 citations

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