Together, these experiments show that Gars∆ETAQ/+ mice display robust and selective peripheral nerve pathology that manifests in a general length-dependent fashion, priming this CMT2D allele for testing treatments and evaluating mechanisms underlying peripheral nerve vulnerability.
R. Simkin, A. Paulo-Ramos, Qiu-Han Lang et al.· Progress in neurobiology· 0 citations
Objective: To determine whether plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are elevated in hospitalised patients with delirium relative to patients with dementia and primary psychiatric disorders (PPD). Methods and analysis: This was a cross-sectional observational study conducted...
M. Kang, D. Eratne, T. Borchard et al.· medRxiv· 0 citations
Subclinical reductions in cardiac output relate to cognitive decline. We examined the relationship between cardiac output and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease pathologies in 153 participants from the Vanderbilt Memory and Aging Project. Linear regression and linear mixed effects regression mo...
Amalia J. Peterson, Yun-Yi Sun, Dan-Dan Liu et al.· Journal of Alzheimer's Disea...· 0 citations
Abstract In-hospital mortality among resuscitated out-of-hospital cardiac arrest (OHCA) patients remains high. Identifying patients who will benefit from intensive care while avoiding prolonged, potentially unnecessary treatments is essential. Blood-based biomarkers provide a novel method for evaluating brain injury. T...
Mikael Laaksonen, Jussi P. Posti, Carita C. Hollmén et al.· Brain Communications· 0 citations
BackgroundNeuroinflammation plays a central role in Alzheimer's disease (AD) pathology and other dementias. EGb 761, a standardized Ginkgo biloba extract, has shown potential anti-inflammatory and neuroprotective properties.ObjectiveThis study evaluated the effects of EGb 761 on plasma proteins related to inflammation...
X. Morató, M. Marquié, J. Tartari et al.· Journal of Alzheimer's Disea...· 0 citations
INTRODUCTION: Biomarkers for monitoring disease activity and treatment response in peripheral neuropathies remain limited. Big tau, a high-molecular-weight isoform of tau, is predominantly expressed in the peripheral nervous system (PNS). We investigated serum levels of big tau, brain-derived tau (BD-tau), and neurofil...
L. Martín-Aguilar, F. González-Ortiz, H. Zetterberg et al.· medRxiv· 0 citations
Inflammation following traumatic brain injury (TBI) may contribute to long-term morbidity. We aimed to characterize plasma interleukin-6 (IL6) trajectory after TBI and assess associations with imaging, biomarkers, and outcomes. Secondary analysis of three prospective multicenter observational cohorts: BIO-AX-TBI (Unite...
Leo Layzell, E. Kodosaki, Xiaoying Sun et al.· Neurotrauma Reports· 0 citations
Alzheimer’s disease (AD) develops silently for years before symptoms emerge, making early identification of at-risk individuals essential for prevention trials and early intervention. We tested whether combining neurophysiological, imaging, and blood biomarkers improves prediction of progression to mild cognitive impai...
Jonathan Gallego-Rudolf, A. I. Wiesman, Y. Yakoub et al.· Science Advances· 0 citations
It is shown that elevated plasma GFAP significantly modulates the association between p-tau217 and both cross-sectional cognitive severity and longitudinal clinical decline, and support that astrocyte reactivity is associated with greater cognitive impairment and faster clinical decline among individuals with elevated...
B. Bellaver, G. Povala, P. C. L. Ferreira et al.· Molecular Neurodegeneration· 0 citations
Results show that, irrespective of the partner antibody, phosphorylated tau assays are more accurate than assays that also measure non-phosphorylated forms of the protein in differentiating Aβ + from Aβ − individuals, and indicate that BD-pTau217 may offer superior sensitivity for the early identification of AD patholo...
H. Gleerup, C. S. Musaeus, Cristiano Santos et al.· Molecular Neurodegeneration...· 0 citations
Many AD pQTLs in CSF were enriched in neuroimmune activation, suggesting a genetic basis for neuroimmune dysregulation in AD, and how genetic variation shapes protein expression in the central nervous system is highlighted.
L. Reus, Chen-Yang Jiang, N. Vilor-Tejedor et al.· Molecular Neurodegeneration...· 0 citations
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