Author

H. Zaki

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Open access Oct 2026

Celecoxib or diallyl trisulfide topical emulgels, alone or in combination, reduce pruritus and inflammatory cascades in a BALB/c mouse model of imiquimod-induced psoriasis

Psoriasis is a chronic, immune-mediated inflammatory skin disease for which no curative treatment currently exists, posing a significant challenge because of its deleterious effects on patients’ quality of life and its substantial economic burden on healthcare systems. Current first-line therapies, including corticoste...

Maha M. Kamel, H. Zaki, Rofida A. Saleh et al. · Pharmacia · 0 citations

Open access Sep 2026

Obeticholic acid attenuates complete freund's adjuvant-induced arthritis in rats through FXR-mediated modulation of TGF-β/TAK1/MKK3/p38 MAPK signaling, inflammation, and oxidative stress.

Rheumatoid arthritis is a chronic autoimmune inflammatory disorder characterized by synovial inflammation, oxidative stress, cartilage destruction, and progressive joint damage. Farnesoid X receptor activation has recently emerged as a potential regulator of immune and inflammatory responses. This study investigated th...

Mohamed Magdy Senna, N. A. Shiha, H. Zaki et al. · InflammoPharmacology · 0 citations

Jul 2026

Synergistic cardioprotection by liraglutide and deferoxamine against doxorubicin-induced cardiotoxicity via modulation of ACSL-4/Nrf-2/GPX-4 signaling.

It is demonstrated that simultaneous targeting of iron overload and antioxidant signaling confers enhanced cardioprotection against Dox-induced injury and the Lira-DFO combination may represent a promising adjunct strategy to mitigate anthracycline-associated cardiotoxicity.

Nada Monir, O. Galal, A. Awad et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations