Author

H. Yasui

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Open access Aug 2026

Prognostic impact of circulating tumor RAS and BRAF mutation dynamics in patients with metastatic colorectal cancer

Summary Post-treatment alterations in circulating tumor DNA (ctDNA) hold potential for refining treatment strategies in metastatic colorectal cancer (mCRC). In this multi-institutional study of 1,391 patients from the SCRUM-Japan GOZILA platform, we evaluated the prognostic significance of post-treatment rat sarcoma vi...

H. Osumi, E. Shinozaki, Yoshiaki Nakamura et al. · iScience · 0 citations

Open access Sep 2026

Efficacy and Safety of Reduced-Dose Chemotherapy Plus Nivolumab in Elderly Advanced Gastric Cancer

Background/Objective: The standard first-line treatment for advanced or recurrent gastric cancer (AGC) includes chemotherapy combined with an immune checkpoint inhibitor or zolbetuximab, but delivering fluoropyrimidine-platinum chemotherapy at standard doses can be difficult in elderly patients. Method: We retrospectiv...

Toshihiko Matsumoto, S. Sugimoto, R. Omori et al. · Gastroenterology Insights · 0 citations