A Generic Numbering Scheme for TMEM16 Scramblases
A generic numbering scheme for TMEM16 scramblases (GNS-TMEM16), modeled on the Ballesteros & Weinstein system established for class A G protein-coupled receptors, is introduced, bringing to light the advantages of corresponding residues identification in different TMEM16 proteins and show that the mammalian scramblase undergoes substantially larger separation at the extracellular groove entrance than either fungal homolog.
Shuai Yan, H. Weinstein
· bioRxiv · 0 citations