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Author

Henkjan J. Verkade

2 papers indexed here

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Review Open access Aug 2026

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive overview of their PK parameters is lacking,...

I. A. Pool, Alise D. E. de Groot, R. J. Keizer et al. · 0 citations
Open access Aug 2026

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatomegaly, and often fibrosis and end-stage...

Angie Molina, L. Trigueros-Motos, Manuela Molina et al. · 0 citations

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