BACKGROUND: In young adults, the risk factors (RFs) for cryptogenic ischemic stroke (CIS) remain unclear. We aimed to investigate the association between recent mechanical venous thrombosis RFs (VTRFs) and young-onset CIS in this multicenter sex- and age-matched case-control study. METHODS: Five hundred forty-six patie...
Julija Valančienė, P. Ylikotila, R. Lautamäki et al.· Stroke· 0 citations
BACKGROUND
Venous thromboembolism (VTE) remains an important complication in critically ill adults despite standard pharmacological thromboprophylaxis. Thrombin generation assays (TGAs) offer a global functional assessment of coagulation by capturing the kinetics and magnitude of thrombin formation and may complement c...
Caseng Zhang, K. Durr, Marc Carrier et al.· Journal of Thrombosis and Ha...· 0 citations
Pro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrhosis, indicating that a new hemostatic balance is reached. TG is determined by prothrombin conversion and thrombin inactiva...
R. Willems, A. Zanetto, E. Campello et al.· Frontiers in Cell and Develo...· 0 citations
A unified theoretical framework is established, grounded in mechanistic rationale and supported by experimentation, to better define the pharmacodynamics of anticoagulation therapy using thrombin generation as a common language to compare anticoagulant effects across drug classes.
Joseph R. Shaw, Dylan Burger, J. Vassart et al.· Pharmacology and Therapeutic...· 0 citations
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