Author

H. Souza

2 papers indexed here

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Open access Oct 2026

Rational Design of N‐2‐(7‐Chloroquinolin‐4‐ylamino)ethyl Amides Active Against Chloroquine‐Resistant Plasmodium falciparum

ABSTRACT Motivated by the antimalarial potential demonstrated by benzamide derivatives of 4‐alkylamino‐7‐chloroquinolines against chloroquine‐resistant Plasmodium falciparum, we designed and synthesized a rational series of N‐2‐(7‐chloroquinolin‐4‐ylamino)ethyl amides to investigate the effects of electron‐withdrawing...

Everton P. Silva, Camila S. Barbosa, A. C. C. Aguiar et al. · Archiv der Pharmazie · 0 citations

Open access Sep 2026

Clean Synthesis of N‐4‐Alkylamino‐7‐chloroquinoline Cyclic Imides: Influence of Lipophilicity on Antibacterial and Ecotoxicological Properties

Motivated by the promising antimicrobial and ecotoxicological effects of 4‐alkylamino‐7‐chloroquinoline and N‐alkylphthalimide derivatives, these privileged nuclei were linked to investigate how lipophilicity influences antibacterial activity and ecotoxicity. For this purpose, seven 4‐alkylamino‐7‐chloroquinolines (2a–...

Agenor P. Luz-Filho, Thais C. Silva, Matheus B. Silva et al. · Chemistry and Biodiversity · 0 citations