Diversity within: a systematic review of intratumor heterogeneity in head and neck squamous cell carcinoma.
OBJECTIVE Head and neck squamous cell carcinoma (HNSCC), is a common, morbid, and frequently lethal malignancy with complex molecular landscapes that influence treatment outcomes and resistance. This systematic review aimed to evaluate the frequency and nature of intratumor heterogeneity (ITH) across multiple tumor reg...