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Author

H. Sackeim

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Review Oct 2026

Brain Stimulation Therapeutic Interventions in Neuropsychiatry: A Cambrian Explosion.

Brain stimulation interventions alter neural activity by applying electrical, magnetic, sonic, or other forms of energy to the nervous system, using invasive or noninvasive methods. In recent years, the basic science and clinical science of neuromodulation have markedly advanced, and the evidence for clinical utility h...

H. Sackeim, Mark S. George · 1 citation
Open access Sep 2026

661. Vagus nerve stimulation reduces suicidal ideation in markedly treatment-resistant depression: RECOVER findings

Abstract Background Individuals with markedly treatment-resistant depression (mTRD) have substantial risk for suicide attempt and completion. Few antidepressant treatments offer benefit for suicide, and it is critical that novel treatments not increase/worsen suicidal ideation (SI) or behavior. Aims & Objectives Assess...

A. Rush, V. Hristidis, V. D. de Leon et al. · 0 citations
Review Open access Oct 2026

Durability of Implanted Cervical Vagus Nerve Stimulation in Treatment-resistant Major Depression: Summary of Findings and Potential Mechanisms of Action

Multiple lines of current exploration are summarized including: engagement of multiple neurotransmitter systems (monoamines and others), anti-inflammatory effects, impact on brain networks/regions associated with depression, evidence of neuroplasticity in brain circuits, modulation of the autonomic nervous system, and...

Karim Al Hasanieh, C. Zorumski, H. Sackeim et al. · 0 citations
Open access Sep 2026

655. Toward a brief, sensitive tool to assess depressive symptom outcomes in research and clinical practice: lessons from the RECOVER trial

Abstract Background In RECOVER, a 12-month, double-blind, randomized, controlled trial (RCT) comparing active versus sham adjunctive vagus nerve stimulation (VNS) in persons with markedly treatment-resistant depression (mTRD), total scores on the Quick Inventory of Depressive Symptomology–Clinician (QIDS-C) and –Self-R...

A. Rush, H. Sackeim, Y.-C. Lee et al. · 0 citations
Review Aug 2026

The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions.

Over 80% of participants who achieved meaningful benefit in symptom, function, or QoL measures after 12 months of active VNS retained these benefits at the 18- and 24-month assessments, demonstrating remarkable durability in participants expected to relapse at high rates.

C. Conway, H. Sackeim, A. Rush et al. · 2 citations

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