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Open access Aug 2026

Multi-layered molecular regulation of complex traits in an advanced intercross line

Most complex-trait-associated variants reside in non-coding regions, yet functional annotation relies heavily on static local expression quantitative trait loci (cis-eQTL), leaving distal and context-dependent regulatory effects unresolved. Here, we leverage an 18-generation chicken advanced intercross line, which subs...

Xiao-Ning Zhu, Cheng-Hao Zhai, Chong Li et al. · 0 citations
Open access Aug 2026

Genome-wide association study reveals putative genetic determinants of longitudinal immune responses to avian influenza and Newcastle disease in chickens

Avian Influenza virus (AIV) and Newcastle disease virus (NDV) are highly contagious immunosuppressive pathogens that cause high mortality rates and economic losses in the global poultry industry. Although vaccination to enhance the host antibody response remains the main control strategy, the genetic basis of this vari...

Haile Berihulay, Wei Luo, Ainong Lao et al. · 0 citations

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