Author

H. Morinaga

2 papers indexed here

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Open access Sep 2026

Size and sequence variation of the Lid of the Cas12a nuclease domain results in a nickase phenotype

Abstract CRISPR–Cas12a nucleases typically induce double-strand breaks (DSBs) to initiate genome editing. However, reliance on DSBs risks chromosomal rearrangements and unintended insertions or deletions at off-target sites. Therefore, engineering nickase variants that cleave only a single DNA strand might enable preci...

Ricardo Villegas Warren, Satoshi N. Omura, Diana León-Castro et al. · Nucleic Acids Research · 0 citations

Case report Open access Aug 2026

Biallelic VPS41 Variants in Autosomal Recessive Spinocerebellar Ataxia 29 Resolved by Long‐Read Sequencing and RNA Analysis

The findings expand the phenotypic spectrum of VPS41‐related disease and highlight the value of long‐read allelic resolution in clarifying pathogenic mechanisms in rare genetic disorders.

Natsuki Nakamura, Y. Nishio, Hiromi Nyuzuki et al. · Molecular Genetics & Genomic... · 0 citations