Isoginkgetin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via the SIRT1/NRF2 pathway.
BACKGROUND Doxorubicin-induced cardiotoxicity (DIC) poses a substantial threat to the prognosis and survival of cancer patients. Ferroptosis, mediated in part by suppression of the SIRT1/NRF2 pathway, has been identified as a critical mechanism underlying DIC. Isoginkgetin (IGK), a naturally occurring biflavonoid with...