Open access
Sep 2026
Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewed intestinal inflammation.
DNA ligase IV (LIG4) is essential for DNA double-strand break (DSB) repair. Hypomorphic LIG4 variants cause LIG4 syndrome, characterized by growth disturbance, increased radiosensitivity, predisposition to malignancies, adaptive immunodeficiency and inflammatory conditions. Most of these manifestations are recapitulate...
Yusuke Yamashita, Hideki Kosako, Takashi Kato et al.
· JCI Insight · 0 citations