Background The programmed cell death-1 (PD-1)/programmed cell death-ligand-1 (PD-L1) pathway is affected in immune checkpoint inhibitor (ICI)-associated acute myocarditis (AM), while this pathway in non-ICI-associated lymphocytic AM (LAM) is unexplored. Objectives This study aimed to assess cardiac levels of PD-L1/PD-1...
E. Ammirati, G. Gallone, Giacomo Veronese et al.· JACC: Advances· 0 citations
Unsupervised and supervised machine learning approaches distinguished HCM from dilated cardiomyopathy and accurately predicted genotype status in early-stage HCM from cell type-resolved transcriptional profiles, revealing widespread genotype-driven remodeling.
E. Adami, Yuri Kim, Sean L. Zheng et al.· Science Translational Medici...· 1 citation
BACKGROUND
Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood.
METHODS AND RESULTS
We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...
W. Linke, Lisa Kümper, A. Fomin et al.· Circulation Research· 0 citations
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