Author

H. Mao

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Open access Sep 2026

Single Amino Acid Disease Mutations Act as Genetic Glues to Drive Neo-substrate Degradation

Disease-associated missense mutations are well known to affect protein turnover by either impairing substrate-ubiquitin ligase interactions or inducing misfolding-triggered protein clearance. Whether such mutations can drive gain-of-function in substrate-selective protein degradation remains under-explored. Here, we de...

Bai-Yun Wang, Chi-Wei Yeh, Hsuan-Mei Lin et al. · bioRxiv · 0 citations

Open access Sep 2026

Transcriptional activation of plant immunity by salicylic acid.

The plant defence hormone salicylic acid (SA) triggers systemic acquired resistance by signalling through its receptor, NON-EXPRESSOR OF PATHOGENESIS-RELATED GENE 1 (NPR1), leading to widespread transcriptional reprogramming1,2. However, the molecular mechanism by which NPR1 senses SA and activates transcription remain...

Song-Wen Zhang, Madeline Gish, Huan Li et al. · Nature · 0 citations