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Author

H. Mahdy

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Sep 2026

Rationale design and synthesis of new quinazoline derivatives as DNA intercalators and topoisomerase II inhibitors.

In pursuit of novel anticancer agents with enhanced potency and selectivity, a new series of quinazoline-based derivatives was rationally designed, synthesized, and biologically evaluated as potential DNA intercalators and topoisomerase II (Topo II) inhibitors. Building upon a previously identified lead compound (6), s...

Amr S. Helmy, Mamdouh F. A. Mohamed, I. Eissa et al. · 0 citations
Aug 2026

Integrated In Silico and In Vitro Discovery of a VEGFR-2-Targeted Anticancer Benzanilide Lead

This integrated study pinpointed ACEB-Cl as a promising VEGFR-2targeted anticancer lead compound with strong inhibitory potency, and a clearly defined mechanism of action, supporting its progression for further improvement.

A. Metwaly, I. Eissa, Walid E. Elgammal et al. · 0 citations
Open access Aug 2026

Integrated design, synthesis, biological evaluation, and computational mechanistic insights of novel benzanilide derivatives as VEGFR-2 targeted anticancer agents

Findings identify compound 7e as a promising VEGFR-2-targeted anticancer lead with strong enzymatic inhibition, potent cytotoxicity, and a well-supported mechanistic profile integrating experimental and computational evidence.

A. Metwaly, Walid E. Elgammal, I. Eissa et al. · 0 citations

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