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Author

H. Lote

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2 papers indexed here

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Review Sep 2026

Abstract A132: A Phase 2 Study to Investigate the Efficacy and Safety of Acoustic Cluster Therapy with Modified FOLFIRINOX in Patients with Locally Advanced and Borderline Resectable Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) remains difficult to treat due to its dense stromal microenvironment, which limits drug penetration and chemotherapy efficacy. Acoustic Cluster Therapy (ACT) is an investigational ultrasound-mediated drug delivery platform designed to enhance intratumoral delivery of system...

Erin Pierce, Ragnar Bendiksen, Amir Snapir et al. · 0 citations
Review Open access Sep 2026

Immuno-Oncology in Pancreatic Ductal Adenocarcinoma: Biological Rationale, Clinical Progress, and Future Directions

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies, characterised by rising incidence, poor long-term survival, and profound resistance to systemic therapy. Its poor prognosis reflects late diagnosis, early metastatic spread, and a uniquely desmoplastic, immunosuppressive tumour microe...

A. Lefas, H. Lote, I. Chau · 0 citations

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