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Author

H. Laayouni

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Open access Jul 2026

Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans

By analysing genome-wide data across 62 diseases, longevity and fertility, it is shown that disease-risk alleles are generally associated with reduced longevity and increased fertility, while alleles that increase both fertility and disease risk have been favoured by natural selection.

Eva Brigos-Barril, Claudia Vasallo, X. Farré et al. · 2 citations

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