Enhanced uric acid degradation attenuates psoriasiform dermatitis via the mtROS–CCL20–CCR6–IL-17 axis
Psoriasis is an interleukin (IL)-23–IL-17–driven chronic inflammatory skin disease characterized by epidermal hyperproliferation. Although psoriasis is frequently associated with hyperuricemia—generally considered a consequence of enhanced local purine metabolism—the direct contribution of uric acid (UA) to psoriatic...