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H. Koba

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2 papers indexed here

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Open access Oct 2026

Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor‐State Heterogeneity and an MMP12 + Macrophage Niche

ABSTRACT Small‐cell lung carcinoma (SCLC) is a highly aggressive tumor with a dismal prognosis among lung cancers. Treatment is failing because of primary or rapidly developing secondary resistance. Recent molecular studies have suggested four SCLC subtypes with unique therapeutic vulnerabilities—ASCL1, NEUROD1, POU2F3...

Naozane Nomura, N. Jimbo, Takaaki Nakanishi et al. · 0 citations
Open access Oct 2026

Neutrophils and CSF1 promote the expansion of monocyte-derived alveolar macrophages in progressive pulmonary fibrosis.

Progressive pulmonary fibrosis (PPF) is a fatal lung condition characterized by persistent inflammation and progressive fibrotic remodeling. Monocyte-derived alveolar macrophages (Mo-AMs) are key drivers of fibrogenesis; however, the mechanisms underlying their persistence in fibrotic lungs remain unclear. Using lineag...

K. Kase, Satoshi Watanabe, Masafumi Horie et al. · 0 citations

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