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Open access Sep 2026

Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study.

This work explores the applicability of new approach methodologies (NAMs) using a read-across approach to predict systemic toxicity with liver as the critical target organ, and derive a point of departurefor the target compound (TC) difenoconazole. Eight conazoles were used as source compounds (SCs), alongside metaboli...

Barira Islam, Jenny Irwan, L. Wijaya et al. · 0 citations
Open access Oct 2026

Unravelling the potential use of metabolomics and in vitro-in vivo extrapolation for plant protection product next generation mixture risk assessment.

Plant protection products (PPPs) contain one or more active substances (AS) and several co-formulants. While AS and PPPs are subjected to different approval requirements, the data requirements for PPPs are generally less comprehensive. New approach methodologies (NAMs) have the potential to detect early biological effe...

A. Stagkos-Georgiadis, D. Deepika, H. Kamp et al. · 0 citations

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